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2 edition of In vitro studies on potential mechanisms of absorption enhancement by hydroxybenzoates found in the catalog.

In vitro studies on potential mechanisms of absorption enhancement by hydroxybenzoates

Andrew John Huson

In vitro studies on potential mechanisms of absorption enhancement by hydroxybenzoates

by Andrew John Huson

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Published by Leicester Polytechnic School of Pharmacy in Leicester .
Written in English


Edition Notes

Thesis (Ph.D.) - Leicester Polytechnic, Leicester 1988.

StatementAndrew John Huson.
ContributionsLeicester Polytechnic. School of Pharmacy.
ID Numbers
Open LibraryOL17892662M

  provides accurate and independent information on more t prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 May ), Cerner Multum™ (updated 4 May ), / Chapter 4 of VAO and Chapter 3 of Update , Update , Update , and Update review the results of animal and in vitro studies published through that investigated the toxicokinetics, mechanisms of action, and disease outcomes of exposure to the herbicides, and the contaminant TCDD, used in Vietnam. The herbicides have not been studied extensively, but in general none of them.

Cancer: New Insights for the Healthcare Professional: Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper Reviews: 1. The authors referred to the results of other studies for possible mechanisms by which the tea catechins decreased postprandial plasma triacylglycerol in their own study. One such potential mechanism is the marked ability of green tea catechins to inhibit gastric and pancreatic lipases.

In vitro modelling methods have shed light on the potential mechanism(s) for the delayed disintegration of IR tablets in the fed stomach (as summarized later in this paper). For BCS class II drugs, the increased presence of solubilizing agents in the upper GI lumen after meal consumption generally enhances the dissolution of the by: 8. These studies assessed the immune effects by in vitro analysis of blood samples that were obtained before and after spaceflights. Most of the experimental studies are of a pre- and postflight nature involving both humans and experimental animals and are divided into categories of short duration (2 weeks) : Anil D Kulkarni, Marie-Francoise Doursout, Asmita Kulkarni, Alamelu Sundaresan, Takehito Miura, Koji.


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In vitro studies on potential mechanisms of absorption enhancement by hydroxybenzoates by Andrew John Huson Download PDF EPUB FB2

In vitro studies on potential mechanisms of absorption enhancement by Hydroxybenzoates Author: Huson, A. ISNI: Awarding Body: Leicester Polytechnic Current Institution: De Montfort University Date of Award: Availability of Full Text.

In addition, in vitro studies often provide useful information regarding the mechanism of permeation enhancement. As an absorption enhancement concept moves to the preclinical stage, the goal is to take what is known from the in vitro studies and apply it in a much more complex, whole animal by: The study was conducted using Caco-2 cells, a widely accepted in vitro model of the human intestinal mucosa for studying drug transport and metabolism as well as cytotoxicity and efficacy of absorption enhancers (Artursson,Werner et al., ).Cited by: In vitro studies of simulated percutaneous absorption: Influence of various enhancers in the release of clonazepam from 2-hydroxyethyl acetate patches Author links open overlay panel P.

Corti a E. Dreassi a P. Mura b P.L. Perruccio cCited by: 6. In an in vitro study, we exposed pulmonary macrophages and red blood cells to fluorescent polystyrene microspheres (1,and microm) and assessed particle uptake by confocal laser. The graphical abstract demonstrated the main results of our study.

This research investigated the effect of camel milk (CM) on the process of colitis in mice. CM could regulate the internal homeostasis by reducing pro‐inflammatory cell proliferation and differentiation, and up‐enhancing anti‐inflammatory cells in the colons of mice.

The AUC and AUMC of in vivo percutaneous absorption of FCT penetration enhancement was higher than that of the control group, AUC and AUMC of the FCTL group were slightly higher than that of the CPE group, and the AUC and AUMC of the FCTM group were significantly higher than that of any other group, indicating that FCT had a facilitating effect on IM transdermal by: 6.

Initial drug absorption enhancement studies on palmitoyl carnitine, a fatty acid ester of carnitine, showed that it is capable of intestinal drug absorption enhancement by means of tight junction opening (paracellular transport) and disruption of brush-border membrane lipids (transcellular transport) [,].

An in depth study on Caco-2 cell monolayers indicated that lytic effects and reduction in cell viability accompanied transport enhancement of hydrophilic macromolecules Cited by: 8.

Hydroxycinnamates including p-coumaric acid, caffeic acid, ferulic acid, sinapic acid, and their esterified/etherified conjugates such as chlorogenic acids are abundant in cereals, coffee, fruit and vegetables.

Studies have shown their potential in the prevention of chronic diseases such as cardiovascular disease and by: This stems from in vitro and in vivo rodent studies and in vitro human studies using cell lines (typically cancerous).

There is little data using primary human lung cells. We addressed this knowledge gap, using highly relevant, primary human alveolar cell models exposed to precisely synthesized and thoroughly characterized MWCNTs.

In vitro skin absorption experiments The in vitro permeation study of A-A-A was determined using Franz-type diffusion cells (Permegear, Hellertown, U.S.A.) (effective diffusional area: cm2) with discs of human skin mounted between the two compartments of the cells.

Fifteen millilitres ofFile Size: KB. From these studies, water-in-oil-in-water (w/o/w) double emulsions show great potential for promoting the oral absorption of hydrophilic drugs.8,9 Water in oil in water double emulsions are complex liquid dispersion systems consisting of inner water, oil, and outer water phases, hydrophilic drugs loaded into the internal aqueous droplets.

Thus, self-double-emulsifying drug delivery systems (SDEDDS) seem Cited by: Neurotoxicity of silver nanoparticles has been confirmed in both in vitro and in vivo studies.

However, the mechanisms of the toxic action have not been fully clarified. A nutritional approach to prevent, slow, or halt the progression of disease is a promising strategy that has been widely investigated. Much epidemiologic data suggests that nutritional intake may influence the development and progression of Alzheimer’s dementia (AD).

Modifiable, environmental causes of AD include potential metabolic derangements caused by dietary insufficiency and or excess Cited by:   4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata.

While recent studies have demonstrated metabolic effects of Cited by: 6. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and.

Figure 2- Potential mechanism for absorption enhancement 84/3/ SEDDS 9. Types of SEDDS Figure 3: It shows lipid formulation classification system (LFCS) On the basis of the water solubility of components, SEDDS can be classified as shown in Figure 3.

94/3/ SEDDS /3/ SEDDS Excipients used in SEDDS formulations 1. Cancer Chemoprevention by Dietary Polyphenols. By Magdy Sayed Aly and Amani Abd ElHamid Mahmoud. Submitted: requiring in vitro studies, animal efficacy and toxicity studies, and eventually lengthy human clinical trials.

One potential mechanism for the chemopreventive effect of tea on carcinogenesis is the strong antioxidant effect of Cited by: 1. The term absorption enhancer usually refers to an agent whose function is to increase absorption by enhancing membrane permeation, rather than increasing solubility, so such agents are sometimes more specifically termed permeation enhancers.

Absorption enhancers have been investigated for at least two decades, Cited by:   3 Potential mechanism of action of Berry polyphenols on anti-diabetic effects.

Recent research from in vitro and in vivo studies supports the anti-diabetic effects of berry polyphenols. “Anti-diabetic” effects are generally associated with achieving and maintain glucose homeostasis.

Insulin is a central player in glucose homeostasis; however, other non-insulin-dependent mechanisms also Cited by:. A saturable absorption mechanism supports the observed nonlinear relationships between blood lead concentration and lead intake found by a variety of studies humans and immature sw87,88 Author: Anca Rădulescu, Steven Lundgren.MECHANISMS OF LOW LEVEL LIGHT THERAPY Michael R.

Hamblin Department of Dermatology, Harvard Medical School, BAR I. Szundi, G.L. Liao and O. Einarsdottir, Near-infrared time-resolved optical absorption studies of the reaction of fully reduced cytochrome c oxidase with dioxygen, Biochemistry 40 () a potential mechanism of.Rectal sacs of Schistocerca gregaria Forskal adults are capable of active absorption of those neutral amino acids naturally found in locust hemolymph.

This absorption occurs against large electrochemical gradients, is inhibited by KCN, and is enhanced only slightly by solvent flow. Metabolic conversion of the amino acids during the translocation across the epithelium is not significant. The.